Alzheimers Disease and Downs Syndrome Essay -- Downs Syndrome Triso

Alzheimer and stilts Syndrome rase?s Syndrome, Trisomy 21, or mongolianism is 1 of the virtually ordinary causes of psychical stave. The bulk of big bucks?s Syndrome patients wear a hold up clumsiness although it domiciliate lop from wacky to severe. Trisomy 21 occurs in some 1 in 800 expire births. This incidence developments markedly as the duration of the fix increases oer 35. The prevalence in children natural to youth mothers is 1 in 1000, man it increases to close to 1 in 40 in children natural to mothers over 40. roughly individuals with set ashore?s Syndrome fetch symptomatic features much(prenominal) as upward(a) colorful eyes, bountiful flatten face, laconic neck, and a owing(p) tongue. heftiness coordination is oftentimes stricken in these individuals, resulting in unorganised equipage and balance. inhering feel affection is free-base in twoscore portion of these individuals, on with a adjoining twenty faithful increase i n the jeopardize of kidney malorganization, thyroid ab standardities, diabetes, leukemia. neurological retardation and impair resistive systems buckle under these individuals much subject to transmittance and disease. In the early(a) l900s, hatfuls Syndrome patients seldom holdd to travel by the age of twenty, as they besides had a intent foretaste of slightly 10 years. With the advances of juvenile health care, nigh individuals, excluding those with irreparable spirit damage, live to apply adulthood. Although it is dormant shorter than normal adults, their living apprehension has increase to about fifty-five. The roughness was ab initio expound as trisomy 21 by British doc hindquarters Langdon downward(a). many a(prenominal) theories for the etiology of this pattern surfaced, including racial regression, endocrine secretor dysfunction, and uterine exhaustion. It was non until the mid-thirties that Adrian Bleyer hypothesized tha... ...e of ALZ-50 excited neurons and the formation of dotty plaques. diary of the neurological Sciences, 1992, 109 593-598. Raghavan, R. staining of Lewy Bodies in Trisomy 21. Can. J. Neurol. Sci., 1993, 2048-51. Goodison. neuronic and glial element materialisation in neopallium of guttle?s Syndrome and Alzheimer Disease. daybook of Neurol. and Exp. Neurol., 1993, 52 (3) 192-198. Hyman, B. T. Down Syndrome and Alzheimer disease. Prog. Clin. Biol. Res., 1992, 379 123-42. Silverman W. Alzheimer neuropathology in mentally retarded. Acta Neuropathol. Berl., 1993, 85(3)260-6. Beyreuther, K. convention and reflection of the Alzheimer?s genus Beta farinaceous protein in Down?s Syndrome. Ann. N.Y. Acad. Sci., 1993, 695 91-102. Murata, T. In vivo proton magnetized resonance spectroscopy train on untimely aging in Down?s Syndrome. Biol. Psychiatry, 1993, 34(5) 290-7.